Necrotizing stomatitis (NS) is an uncommon oral ulceration associated with reduced immunity, recent illness, and unusual life stress. It can be seen in malnourished children and HIV-infected adults, but it is very uncommon in non-HIV adults. Objective. To present a case of NS in a non-HIV adult. Methodology. We present a previously misdiagnosed case of NS in a non-HIV 27-year-old female whose immunity was compromised by several factors including malnutrition, chronic anemia, drug treatment of rheumatoid arthritis, and fibrous TMJ ankylosis. Several factors mitigating the diagnosis and successful treatment of this patient are discussed. Conclusion. This presentation highlights a challenging case of NS complicated by several unusual factors. It serves to educate the dental practitioners on the interplay of factors which if not addressed will mitigate successful management of the patient.